Studies on Anthelmintics. XXI

Studies on echinococcosis. XXI. Electron microscopical observations on general structure of larval tissue of multilocular Echinococcus.

Studies of drugs given before anaesthesia. XXI. Droperidol.

Droperidol 5 mg and 10 mg and diazepam 10 mg were compared in premedication studies with morphine 10 mg and saline. Droperidol caused less hypnosis than either morphine or diazepam, and its use was associated with a much higher incidence of anxiety among patients than was observed in the group who had received saline only. Dizziness and restlessness were also significant features of the action ...

Xxi. Neurology

2. Transient Probability Distributions of Nerve Impulse Intervals, S. B. Thesis, Department of Physics, M.I. T., June 1964. The time evolution of the distribution of nerve-impulse intervals was examined by measuring histograms at varying times in the stimulus cycle. The distribution width was found to vary inversely as the stimulus strength. There is an indication that the width also depends up...

Anthelmintics – From Discovery to Resistance

The scientific meeting entitled 'Anthelmintics: From Discovery to Resistance' was held in San Francisco in February 2014. The themes of the meeting were drug discovery, modes of action and resistance. Both human and veterinary parasites were covered in the oral and poster presentations. The attendees were from both academic and industrial backgrounds. In the present article we introduce a numbe...

Studies on Transfer Ribonucleic Acid-Ribosome Complexes XXI. EFFECT OF ANTIBIOTICS ON PEPTIDYL-PURO?(/IYCIN SYNTHESIS BY MAMMALIAN POLYRIBOSOMES*

The effect of antibiotics and other agents on-peptide bond synthesis by mammalian polyribosomes was determined by studying peptidyl-puromycin synthesis. Sparsomycin, anisomycin, cycloheximide, gougerotin, blasticidin S, and cryptopleurine inhibited the reaction. Sparsomycin and anisomytin inhibited the peptidyl-puromycin synthesis competitively with respect to puromycin. Arabinose analogs of pu...